SARM1: Difference between revisions
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== Function == | == Function == | ||
'''SARM1''' or '''NAD(+) hydrolase''' or '''sterile alpha and TIR motif-containing protein 1''' or '''NADase''' is a NAD-cleaving enzyme whose activation triggers axon destruction. | '''SARM1''' or '''NAD(+) hydrolase''' or '''sterile alpha and TIR motif-containing protein 1''' or '''NADase''' is a NAD-cleaving enzyme whose activation triggers axon destruction. SARM1 is a metabolic sensor responding to an increased NMN/NAD+ ratio by cleaving residual NAD+ and inducing axonal demise<ref>PMID:33657413</ref>. SARM1-induced axon destruction can be counteracted by increased NAD+ synthesis<ref>PMID:25908823</ref>. | ||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
The 3D structure of SARM1 shows the octamer structure with outer ring dimension of 200A, inner ring of 45A and thickness of 60A<ref>PMID:33053563</ref>. | The 3D structure of SARM1 shows the <scene name='91/918463/Cv/2'>octamer structure</scene> with outer ring dimension of 200A, inner ring of 45A and thickness of 60A<ref>PMID:33053563</ref>. The 3 domains of SARM1 are ARM, SAM and TIR. The interaction of the ARM and TIR domains cause the autoinhibition of SARM1. NAD(+) binding pocket is at the concave side of the ARM domain. | ||
==3D structures of SARM1== | ==3D structures of SARM1== | ||
[[SARM1 3D structures]] | [[SARM1 3D structures]] | ||
Revision as of 10:03, 3 August 2022
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