SARM1: Difference between revisions

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== Function ==

'''SARM1''' or '''NAD(+) hydrolase''' or '''sterile alpha and TIR motif-containing protein 1''' or '''NADase''' is a NAD-cleaving enzyme whose activation triggers axon destruction. SARM1 is a metabolic sensor responding to an increased NMN/NAD+ ratio by cleaving residual NAD+ and inducing axonal demise<ref>PMID:33657413</ref>. SARM1-induced axon destruction can be counteracted by increased NAD+ synthesis<ref>PMID:25908823</ref>.

'''SARM1''' or '''NAD(+) hydrolase''' or '''sterile alpha and TIR motif-containing protein 1''' or '''NADase''' is a NAD-cleaving enzyme<ref>PMID:28334607</ref> whose activation triggers Wallerian axon destruction after injury<ref>PMID:22678360</ref>. SARM1 is thought to be a metabolic sensor responding to an increased NMN/NAD+ ratio by cleaving residual NAD+ and inducing axonal demise<ref>PMID:33657413</ref>. SARM1-induced axon destruction can be counteracted by increased NAD+ synthesis<ref>PMID:25908823</ref>.

== Disease ==

SARM1 mutations were found in ALS patients<ref>PMID:34796871</ref>.

SARM1 mutations were found in ALS patients<ref>PMID:34796871</ref>. SARM1 induces axonal degeneration after nerve injury<ref>PMID:23946415</ref> and in other neuropathological conditions, such as chemotherapy induced peripheral neuropathy (CIPN), a dose-restricting chemotherapy side effect<ref>PMID:27797810</ref>,<ref>PMID:33318563</ref>. Consistent with its pro-degenerative function, genetic ablation of SARM1 protects against axonal and other types of neuronal degeneration, without inflicting any apparent impediments on the animal models<ref>PMID:30842236</ref>. Particularly, it was demonstrated that SARM1 ablation provides protection against CIPN induced by the widely used chemotherapy agents vincristine<ref>PMID:31484833</ref>, cisplatin and paclitaxel<ref>PMID:33964142</ref>.

== Structural highlights ==

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@@ Line 3: / Line 3: @@
 == Function ==
-'''SARM1''' or '''NAD(+) hydrolase''' or '''sterile alpha and TIR motif-containing protein 1''' or '''NADase''' is a NAD-cleaving enzyme whose activation triggers axon destruction. SARM1 is a metabolic sensor responding to an increased NMN/NAD+ ratio by cleaving residual NAD+ and inducing axonal demise<ref>PMID:33657413</ref>. SARM1-induced axon destruction can be counteracted by increased NAD+ synthesis<ref>PMID:25908823</ref>.
+'''SARM1''' or '''NAD(+) hydrolase''' or '''sterile alpha and TIR motif-containing protein 1''' or '''NADase''' is a NAD-cleaving enzyme<ref>PMID:28334607</ref> whose activation triggers Wallerian axon destruction after injury<ref>PMID:22678360</ref>. SARM1 is thought to be a metabolic sensor responding to an increased NMN/NAD+ ratio by cleaving residual NAD+ and inducing axonal demise<ref>PMID:33657413</ref>. SARM1-induced axon destruction can be counteracted by increased NAD+ synthesis<ref>PMID:25908823</ref>.
 == Disease ==
-SARM1 mutations were found in ALS patients<ref>PMID:34796871</ref>.
+SARM1 mutations were found in ALS patients<ref>PMID:34796871</ref>.  SARM1 induces axonal degeneration after nerve injury<ref>PMID:23946415</ref> and in other neuropathological conditions, such as chemotherapy induced peripheral neuropathy (CIPN), a dose-restricting chemotherapy side effect<ref>PMID:27797810</ref>,<ref>PMID:33318563</ref>. Consistent with its pro-degenerative function, genetic ablation of SARM1 protects against axonal and other types of neuronal degeneration, without inflicting any apparent impediments on the animal models<ref>PMID:30842236</ref>. Particularly, it was demonstrated that SARM1 ablation provides protection against CIPN induced by the widely used chemotherapy agents vincristine<ref>PMID:31484833</ref>, cisplatin and paclitaxel<ref>PMID:33964142</ref>.
 == Structural highlights ==