7ups: Difference between revisions
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==Structural study of Legionella pneumophila effector DotY (Lpg0294)== | ==Structural study of Legionella pneumophila effector DotY (Lpg0294)== | ||
<StructureSection load='7ups' size='340' side='right'caption='[[7ups]]' scene=''> | <StructureSection load='7ups' size='340' side='right'caption='[[7ups]], [[Resolution|resolution]] 2.43Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UPS FirstGlance]. <br> | <table><tr><td colspan='2'>[[7ups]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._Philadelphia_1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UPS FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ups FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ups OCA], [https://pdbe.org/7ups PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ups RCSB], [https://www.ebi.ac.uk/pdbsum/7ups PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ups ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ups FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ups OCA], [https://pdbe.org/7ups PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ups RCSB], [https://www.ebi.ac.uk/pdbsum/7ups PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ups ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/DOTY_LEGPH DOTY_LEGPH] Component of the Dot/Icm type IVB secretion system (T4BSS), which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:32513920). Part of a subcomplex which recruits effector proteins and delivers them to the core transmembrane subcomplex (PubMed:32513920). DotY and DotZ play a role in effector translocation, but are not essential and do not influence the stability of the subcomplex main components (PubMed:34816517). The DotY/DotZ main function is to optimize secretion by modulating the delivery trajectory of the IcmSW module and the localization of the machinery to the poles (PubMed:34816517).<ref>PMID:32513920</ref> <ref>PMID:34816517</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Legionella pneumophila subsp. pneumophila str. Philadelphia 1]] | |||
[[Category: Chung IYW]] | [[Category: Chung IYW]] | ||
[[Category: Cygler M]] | [[Category: Cygler M]] | ||
