7wrg: Difference between revisions
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==Crystal structure of full-length kinesin-3 KLP-6== | ==Crystal structure of full-length kinesin-3 KLP-6== | ||
<StructureSection load='7wrg' size='340' side='right'caption='[[7wrg]]' scene=''> | <StructureSection load='7wrg' size='340' side='right'caption='[[7wrg]], [[Resolution|resolution]] 3.16Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WRG FirstGlance]. <br> | <table><tr><td colspan='2'>[[7wrg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WRG FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wrg OCA], [https://pdbe.org/7wrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wrg RCSB], [https://www.ebi.ac.uk/pdbsum/7wrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wrg ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.16Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wrg OCA], [https://pdbe.org/7wrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wrg RCSB], [https://www.ebi.ac.uk/pdbsum/7wrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wrg ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/G5EFQ4_CAEEL G5EFQ4_CAEEL] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Autoinhibition of kinesin-3 ensures the proper spatiotemporal control of the motor activity for intracellular transport, but the underlying mechanism remains elusive. Here, we determine the full-length structure of kinesin-3 KLP-6 in a compact self-folded state. Unexpectedly, all the internal coiled-coil segments and domains in KLP-6 cooperate to successively lock down the neck and motor domains. The first coiled-coil segment is melted into several short helices that work with the motor domain to restrain the entire neck domain. The second coiled-coil segment associates with its neighboring FHA and MBS domains and integrates with the tail MATH domain to form a supramodule that synergistically wraps around the motor domain to trap the nucleotide and hinder the microtubule binding. This multilevel-lockdown mechanism for autoinhibition could be applicable to other kinesin-3 motors. | |||
The architecture of kinesin-3 KLP-6 reveals a multilevel-lockdown mechanism for autoinhibition.,Wang W, Ren J, Song W, Zhang Y, Feng W Nat Commun. 2022 Jul 25;13(1):4281. doi: 10.1038/s41467-022-32048-y. PMID:35879313<ref>PMID:35879313</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7wrg" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Caenorhabditis elegans]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Feng W]] | [[Category: Feng W]] | ||
Latest revision as of 17:43, 29 November 2023
Crystal structure of full-length kinesin-3 KLP-6
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