7yxa: Difference between revisions
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==XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608== | ==XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608== | ||
<StructureSection load='7yxa' size='340' side='right'caption='[[7yxa]]' scene=''> | <StructureSection load='7yxa' size='340' side='right'caption='[[7yxa]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YXA FirstGlance]. <br> | <table><tr><td colspan='2'>[[7yxa]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YXA FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yxa OCA], [https://pdbe.org/7yxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yxa RCSB], [https://www.ebi.ac.uk/pdbsum/7yxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yxa ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B2O:4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic+acid'>B2O</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yxa OCA], [https://pdbe.org/7yxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yxa RCSB], [https://www.ebi.ac.uk/pdbsum/7yxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yxa ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/S1PR5_HUMAN S1PR5_HUMAN]] Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Borshchevskiy V]] | [[Category: Borshchevskiy, V]] | ||
[[Category: Bourenkov G]] | [[Category: Bourenkov, G]] | ||
[[Category: Bukhdruker S]] | [[Category: Bukhdruker, S]] | ||
[[Category: Cherezov V]] | [[Category: Cherezov, V]] | ||
[[Category: Cho Y]] | [[Category: Cho, Y]] | ||
[[Category: Ergasheva M]] | [[Category: Ergasheva, M]] | ||
[[Category: Gerasimov A]] | [[Category: Gerasimov, A]] | ||
[[Category: Gordeliy V]] | [[Category: Gordeliy, V]] | ||
[[Category: Gusach A]] | [[Category: Gusach, A]] | ||
[[Category: Gushchin I]] | [[Category: Gushchin, I]] | ||
[[Category: Hu H]] | [[Category: Hu, H]] | ||
[[Category: Huyn | [[Category: Huyn, H J]] | ||
[[Category: Khorn P]] | [[Category: Khorn, P]] | ||
[[Category: Khusainov G]] | [[Category: Khusainov, G]] | ||
[[Category: Kovalev K]] | [[Category: Kovalev, K]] | ||
[[Category: Kovaleva M]] | [[Category: Kovaleva, M]] | ||
[[Category: Liu W]] | [[Category: Liu, W]] | ||
[[Category: Luginina A]] | [[Category: Luginina, A]] | ||
[[Category: Lyapina E]] | [[Category: Lyapina, E]] | ||
[[Category: Marin E]] | [[Category: Marin, E]] | ||
[[Category: Mishin A]] | [[Category: Mishin, A]] | ||
[[Category: Okhrimenko I]] | [[Category: Okhrimenko, I]] | ||
[[Category: Orekhov P]] | [[Category: Orekhov, P]] | ||
[[Category: Park G]] | [[Category: Park, G]] | ||
[[Category: Park J]] | [[Category: Park, J]] | ||
[[Category: Park S]] | [[Category: Park, S]] | ||
[[Category: Popov P]] | [[Category: Popov, P]] | ||
[[Category: Rogachev A]] | [[Category: Rogachev, A]] | ||
[[Category: Shevtsov M]] | [[Category: Shevtsov, M]] | ||
[[Category: Vakhrameev D]] | [[Category: Vakhrameev, D]] | ||
[[Category: Weierstall U]] | [[Category: Weierstall, U]] | ||
[[Category: G-protein coupled receptor]] | |||
[[Category: Gpcr]] | |||
[[Category: Membrane protein]] | |||
[[Category: S1p5]] | |||
[[Category: Serial femtosecond crystallography]] | |||
[[Category: Sfx]] | |||
[[Category: Sphingosine-1-phosphate]] | |||
[[Category: Sphingosine-1-phosphate receptor]] | |||
[[Category: X-ray free electron laser]] | |||
[[Category: Xfel]] | |||
Revision as of 06:48, 18 August 2022
XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Large Structures
- Borshchevskiy, V
- Bourenkov, G
- Bukhdruker, S
- Cherezov, V
- Cho, Y
- Ergasheva, M
- Gerasimov, A
- Gordeliy, V
- Gusach, A
- Gushchin, I
- Hu, H
- Huyn, H J
- Khorn, P
- Khusainov, G
- Kovalev, K
- Kovaleva, M
- Liu, W
- Luginina, A
- Lyapina, E
- Marin, E
- Mishin, A
- Okhrimenko, I
- Orekhov, P
- Park, G
- Park, J
- Park, S
- Popov, P
- Rogachev, A
- Shevtsov, M
- Vakhrameev, D
- Weierstall, U
- G-protein coupled receptor
- Gpcr
- Membrane protein
- S1p5
- Serial femtosecond crystallography
- Sfx
- Sphingosine-1-phosphate
- Sphingosine-1-phosphate receptor
- X-ray free electron laser
- Xfel
