1hx0: Difference between revisions

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[[Image:1hx0.gif|left|200px]]
{{Seed}}
[[Image:1hx0.png|left|200px]]


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{{STRUCTURE_1hx0|  PDB=1hx0  |  SCENE=  }}  
{{STRUCTURE_1hx0|  PDB=1hx0  |  SCENE=  }}  


'''STRUCTURE OF PIG PANCREATIC ALPHA-AMYLASE COMPLEXED WITH THE "TRUNCATE" ACARBOSE MOLECULE (PSEUDOTRISACCHARIDE)'''
===STRUCTURE OF PIG PANCREATIC ALPHA-AMYLASE COMPLEXED WITH THE "TRUNCATE" ACARBOSE MOLECULE (PSEUDOTRISACCHARIDE)===




==Overview==
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Mammalian alpha-amylases catalyze the hydrolysis of alpha-linked glucose polymers according to a complex processive mechanism. We have determined the X-ray structures of porcine pancreatic alpha-amylase complexes with the smallest molecule of the trestatin family (acarviosine-glucose) which inhibits porcine pancreatic alpha-amylase and yet is not hydrolyzed by the enzyme. A structure analysis at 1.38 A resolution of this complex allowed for a clear identification of a genuine single hexasaccharide species composed of two alpha-1,4-linked original molecules bound to the active site of the enzyme. The structural results supported by mass spectrometry experiments provide evidence for an enzymatically catalyzed condensation reaction in the crystal.
The line below this paragraph, {{ABSTRACT_PUBMED_11412124}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11412124 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11412124}}


==About this Structure==
==About this Structure==
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Pancrea]]
[[Category: Pancrea]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:18:42 2008''
 
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