1hx2: Difference between revisions

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[[Image:1hx2.jpg|left|200px]]
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[[Image:1hx2.png|left|200px]]


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{{STRUCTURE_1hx2|  PDB=1hx2  |  SCENE=  }}  
{{STRUCTURE_1hx2|  PDB=1hx2  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF BSTI, A TRYPSIN INHIBITOR FROM BOMBINA BOMBINA.'''
===SOLUTION STRUCTURE OF BSTI, A TRYPSIN INHIBITOR FROM BOMBINA BOMBINA.===




==Overview==
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The three-dimensional solution structure of BSTI, a trypsin inhibitor from the European frog Bombina bombina, has been solved using (1)H NMR spectroscopy. The 60 amino acid protein contains five disulfide bonds, which were unambiguously determined to be Cys (4--38), Cys (13--34), Cys (17--30), Cys (21--60), and Cys (40--54) by experimental restraints and subsequent structure calculations. The main elements of secondary structure are four beta-strands, arranged as two small antiparallel beta-sheets. The overall fold of BSTI is disk shaped and is characterized by the lack of a hydrophobic core. The presumed active site is located on a loop comprising residues 21--34, which is a relatively disordered region similar to that seen in many other protease inhibitors. However, the overall fold is different to other known protease inhibitors with the exception of a small family of inhibitors isolated from nematodes of the family Ascaris and recently also from the haemolymph of Apis mellifera. BSTI may thus be classified as a new member of this recently discovered family of protease inhibitors.
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{{ABSTRACT_PUBMED_11294627}}


==About this Structure==
==About this Structure==
1HX2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bombina_bombina Bombina bombina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HX2 OCA].  
1HX2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bombina_bombina Bombina bombina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HX2 OCA].  


==Reference==
==Reference==
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[[Category: Scanlon, M J.]]
[[Category: Scanlon, M J.]]
[[Category: Beta-sheet disulfide-rich]]
[[Category: Beta-sheet disulfide-rich]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:18:56 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:02:59 2008''

Revision as of 07:03, 1 July 2008

File:1hx2.png

Template:STRUCTURE 1hx2

SOLUTION STRUCTURE OF BSTI, A TRYPSIN INHIBITOR FROM BOMBINA BOMBINA.

Template:ABSTRACT PUBMED 11294627

About this Structure

1HX2 is a Single protein structure of sequence from Bombina bombina. Full experimental information is available from OCA.

Reference

Solution structure of BSTI: a new trypsin inhibitor from skin secretions of Bombina bombina., Rosengren KJ, Daly NL, Scanlon MJ, Craik DJ, Biochemistry. 2001 Apr 17;40(15):4601-9. PMID:11294627

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