8dyk: Difference between revisions
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==Room temperature neutron structure of a fluorescent Ag8 cluster templated by a multistranded DNA scaffold== | |||
<StructureSection load='8dyk' size='340' side='right'caption='[[8dyk]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8dyk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DYK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Neutron Diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AG:SILVER+ION'>AG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dyk OCA], [https://pdbe.org/8dyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dyk RCSB], [https://www.ebi.ac.uk/pdbsum/8dyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dyk ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
When strands of DNA encapsulate silver clusters, supramolecular optical chromophores develop. However, how a particular structure endows a specific spectrum remains poorly understood. Here, we used neutron diffraction to map protonation in (A(2)C(4))(2)-Ag(8), a green-emitting fluorophore with a "Big Dipper" arrangement of silvers. The DNA host has two substructures with distinct protonation patterns. Three cytosines from each strand collectively chelate handle-like array of three silvers, and calorimetry studies suggest Ag(+) cross-links. The twisted cytosines are further joined by hydrogen bonds from fully protonated amines. The adenines and their neighboring cytosine from each strand anchor a dipper-like group of five silvers via their deprotonated endo- and exocyclic nitrogens. Typically, exocyclic amines are strongly basic, so their acidification and deprotonation in (A(2)C(4))(2)-Ag(8) suggest that silvers perturb the electron distribution in the aromatic nucleobases. The different protonation states in (A(2)C(4))(2)-Ag(8) suggest that atomic level structures can pinpoint how to control and tune the electronic spectra of these nanoscale chromophores. | |||
Mapping H(+) in the Nanoscale (A(2)C(4))(2)-Ag(8) Fluorophore.,David F, Setzler C, Sorescu A, Lieberman RL, Meilleur F, Petty JT J Phys Chem Lett. 2022 Dec 8;13(48):11317-11322. doi: , 10.1021/acs.jpclett.2c03161. Epub 2022 Dec 1. PMID:36453924<ref>PMID:36453924</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 8dyk" style="background-color:#fffaf0;"></div> | ||
[[Category: Lieberman | == References == | ||
[[Category: Petty | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Lieberman RL]] | |||
[[Category: Meilleur F]] | |||
[[Category: Petty JT]] | |||
Latest revision as of 10:37, 2 August 2023
Room temperature neutron structure of a fluorescent Ag8 cluster templated by a multistranded DNA scaffold
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