7t7a: Difference between revisions
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<StructureSection load='7t7a' size='340' side='right'caption='[[7t7a]], [[Resolution|resolution]] 1.79Å' scene=''> | <StructureSection load='7t7a' size='340' side='right'caption='[[7t7a]], [[Resolution|resolution]] 1.79Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7t7a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7A FirstGlance]. <br> | <table><tr><td colspan='2'>[[7t7a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7A FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7a OCA], [https://pdbe.org/7t7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7a RCSB], [https://www.ebi.ac.uk/pdbsum/7t7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7a ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7a OCA], [https://pdbe.org/7t7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7a RCSB], [https://www.ebi.ac.uk/pdbsum/7t7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7a ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN]] Noonan syndrome-like disorder with loose anagen hair. The disease is caused by variants affecting the gene represented in this entry. | [[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN]] Noonan syndrome-like disorder with loose anagen hair. The disease is caused by variants affecting the gene represented in this entry. | ||
== Function == | == Function == | ||
[[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN]] Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.<ref>PMID:10783161</ref> <ref>PMID:16630891</ref> <ref>PMID:25137548</ref> | [[https://www.uniprot.org/uniprot/SHOC2_HUMAN SHOC2_HUMAN]] Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes.<ref>PMID:10783161</ref> <ref>PMID:16630891</ref> <ref>PMID:25137548</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Aguirre | [[Category: Aguirre J]] | ||
[[Category: Bian | [[Category: Bian Y]] | ||
[[Category: Fuller | [[Category: Fuller C]] | ||
[[Category: Hajian | [[Category: Hajian B]] | ||
[[Category: Kwon | [[Category: Kwon J]] | ||
[[Category: Lemke | [[Category: Lemke C]] | ||
