7y63: Difference between revisions
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==ApoSIDT2-pH7.4== | |||
<StructureSection load='7y63' size='340' side='right'caption='[[7y63]], [[Resolution|resolution]] 3.16Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7y63]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y63 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y63 OCA], [https://pdbe.org/7y63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y63 RCSB], [https://www.ebi.ac.uk/pdbsum/7y63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y63 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SIDT2_HUMAN SIDT2_HUMAN] Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity).[UniProtKB:Q8CIF6]<ref>PMID:27046251</ref> <ref>PMID:27846365</ref> <ref>PMID:28277980</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Gong DS]] | |||
