8ar3: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8ar3 is ~~ON HOLD~~

==Solution structure of TLR9 transmembrane and cytoplasmic juxtamembrane regions==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8ar3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AR3 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ar3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ar3 OCA], [https://pdbe.org/8ar3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ar3 RCSB], [https://www.ebi.ac.uk/pdbsum/8ar3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ar3 ProSAT]</span></td></tr>

[[Category: ~~Unreleased~~ Structures]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/TLR9_HUMAN TLR9_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366).[UniProtKB:Q9EQU3]<ref>PMID:11564765</ref> <ref>PMID:17932028</ref> <ref>PMID:23857366</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Arseniev AS]]

[[Category: Goncharuk MV]]

[[Category: Goncharuk SA]]

[[Category: Kornilov FD]]

[[Category: Mineev KS]]

[[Category: Shabalkina AV]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8ar3 is ON HOLD
+==Solution structure of TLR9 transmembrane and cytoplasmic juxtamembrane regions==
+<StructureSection load='8ar3' size='340' side='right'caption='[[8ar3]]' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8ar3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AR3 FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ar3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ar3 OCA], [https://pdbe.org/8ar3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ar3 RCSB], [https://www.ebi.ac.uk/pdbsum/8ar3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ar3 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TLR9_HUMAN TLR9_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028). Controls lymphocyte response to Helicobacter infection (By similarity). Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366).[UniProtKB:Q9EQU3]<ref>PMID:11564765</ref> <ref>PMID:17932028</ref> <ref>PMID:23857366</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Arseniev AS]]
+[[Category: Goncharuk MV]]
+[[Category: Goncharuk SA]]
+[[Category: Kornilov FD]]
+[[Category: Mineev KS]]
+[[Category: Shabalkina AV]]