8e1o: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
Line 1: Line 1:
'''Unreleased structure'''


The entry 8e1o is ON HOLD  until Paper Publication
==Crystal structure of hTEAD2 bound to a methoxypyridine lipid pocket binder==
 
<StructureSection load='8e1o' size='340' side='right'caption='[[8e1o]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
Authors: Noland, C.L., Dey, A., Zbieg, J., Crawford, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8e1o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E1O FirstGlance]. <br>
Description: Crystal structure of hTEAD2 bound to a methoxypyridine lipid pocket binder
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=Y2S:5-methoxy-N-({3-[2-(methylamino)-2-oxoethyl]phenyl}methyl)-4-{(E)-2-[trans-4-(trifluoromethyl)cyclohexyl]ethenyl}pyridine-2-carboxamide'>Y2S</scene></td></tr>
[[Category: Dey, A]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e1o OCA], [https://pdbe.org/8e1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e1o RCSB], [https://www.ebi.ac.uk/pdbsum/8e1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e1o ProSAT]</span></td></tr>
[[Category: Zbieg, J]]
</table>
[[Category: Noland, C.L]]
== Function ==
[[Category: Crawford, J]]
[https://www.uniprot.org/uniprot/TEAD2_HUMAN TEAD2_HUMAN] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.<ref>PMID:18579750</ref> <ref>PMID:19324877</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Crawford J]]
[[Category: Dey A]]
[[Category: Noland CL]]
[[Category: Zbieg J]]
Retrieved from "https://proteopedia.org/8e1o"