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==Backbone 1H, 13C, and 15N Chemical Shift Assignments for LMO2(LIM2)-Ldb1(LID)==
==Backbone 1H, 13C, and 15N Chemical Shift Assignments for LMO2(LIM2)-Ldb1(LID)==
<StructureSection load='2lxd' size='340' side='right'caption='[[2lxd]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2lxd' size='340' side='right'caption='[[2lxd]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2lxd]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2l3k 2l3k]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LXD FirstGlance]. <br>
<table><tr><td colspan='2'>This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2l3k 2l3k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LXD FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxd OCA], [https://pdbe.org/2lxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lxd RCSB], [https://www.ebi.ac.uk/pdbsum/2lxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lxd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxd OCA], [https://pdbe.org/2lxd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lxd RCSB], [https://www.ebi.ac.uk/pdbsum/2lxd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lxd ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/RBTN2_MOUSE RBTN2_MOUSE]] Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.<ref>PMID:9391090</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
LIM-only protein 2, Lmo2, is a regulatory protein that is essential for hematopoietic development and inappropriate overexpression of Lmo2 in T cells contributes to T cell leukaemia. It exerts its functions by mediating protein-protein interactions and nucleating multicomponent transcriptional complexes. Lmo2 interacts with LIM domain binding protein 1 (Ldb1) through the tandem LIM domains of Lmo2 and the LIM interaction domain (LID) of Ldb1. Here we present the solution structure of the LIM2 domain of Lmo2 bound to Ldb1(LID) . The ordered regions of Ldb1 in this complex correspond well with binding hotspots previously defined by mutagenic studies. Comparisons of this Lmo2(LIM2) -Ldb1(LID) structure with previously determined structures of the Lmo2/Ldb1(LID) complexes lead to the conclusion that modular binding of tandem LIM domains in Lmo2 to tandem linear motifs in Ldb1 is accompanied by several disorder-to-order transitions and/or conformational changes in both proteins. Proteins 2012. (c) 2012 The Protein Society.
Solution structure of a tethered Lmo2(LIM2) /Ldb1(LID) complex.,Dastmalchi S, Wilkinson-White L, Kwan AH, Gamsjaeger R, Mackay JP, Matthews JM Protein Sci. 2012 Aug 30. doi: 10.1002/pro.2153. PMID:22936624<ref>PMID:22936624</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2lxd" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Dastmalchi, S]]
[[Category: Dastmalchi S]]
[[Category: Gamsjaeger, R]]
[[Category: Gamsjaeger R]]
[[Category: Kwan, A H]]
[[Category: Kwan AH]]
[[Category: Mackay, J P]]
[[Category: Mackay JP]]
[[Category: Matthews, J M]]
[[Category: Matthews JM]]
[[Category: Wilkinson-White, L]]
[[Category: Wilkinson-White L]]
[[Category: Ldb1]]
[[Category: Lim]]
[[Category: Transcription]]

Revision as of 10:18, 31 August 2022

Backbone 1H, 13C, and 15N Chemical Shift Assignments for LMO2(LIM2)-Ldb1(LID)

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