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==Crystal structure of mouse glyoxalase I complexed with indomethacin==
==Crystal structure of mouse glyoxalase I complexed with indomethacin==
<StructureSection load='4kyk' size='340' side='right'caption='[[4kyk]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4kyk' size='340' side='right'caption='[[4kyk]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4kyk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KYK FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KYK FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMN:INDOMETHACIN'>IMN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kyk OCA], [https://pdbe.org/4kyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kyk RCSB], [https://www.ebi.ac.uk/pdbsum/4kyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kyk ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2za0|2za0]], [[4kyh|4kyh]]</div></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lactoylglutathione_lyase Lactoylglutathione lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.4.1.5 4.4.1.5] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kyk OCA], [https://pdbe.org/4kyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kyk RCSB], [https://www.ebi.ac.uk/pdbsum/4kyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kyk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/LGUL_MOUSE LGUL_MOUSE]] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity).
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Old drugs new tricks: Zopolrestat, an aldose reductase inhibitor developed by Pfizer for the treatment of diabetic complications, is a potent competition inhibitor of human glyoxalase I (GLOI) in vitro. Crystal structures of GLOI in complex with zopolrestat and indomethacin, a nonsteroidal anti-inflammatory drug and moderate inhibitor of GLOI, provide a structural basis for the development of novel GLOI inhibitors with excellent pharmacokinetics profiles.
Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis.,Zhai J, Zhang H, Zhang L, Zhao Y, Chen S, Chen Y, Peng X, Li Q, Yuan M, Hu X ChemMedChem. 2013 Jul 15. doi: 10.1002/cmdc.201300243. PMID:23857942<ref>PMID:23857942</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4kyk" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Glyoxalase 3D structures|Glyoxalase 3D structures]]
*[[Glyoxalase 3D structures|Glyoxalase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lactoylglutathione lyase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chen, S]]
[[Category: Chen S]]
[[Category: Chen, Y]]
[[Category: Chen Y]]
[[Category: Yuan, M]]
[[Category: Yuan M]]
[[Category: Zhai, J]]
[[Category: Zhai J]]
[[Category: Zhang, H]]
[[Category: Zhang H]]
[[Category: Zhang, L]]
[[Category: Zhang L]]
[[Category: Zhao, Y]]
[[Category: Zhao Y]]
[[Category: Lactoylglutachione lyase]]
[[Category: Lyase-lyase inhibitor complex]]

Revision as of 10:46, 31 August 2022

Crystal structure of mouse glyoxalase I complexed with indomethacin

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