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==Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori==
==Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori==
<StructureSection load='4qla' size='340' side='right'caption='[[4qla]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4qla' size='340' side='right'caption='[[4qla]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4qla]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QLA FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QLA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qla OCA], [https://pdbe.org/4qla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qla RCSB], [https://www.ebi.ac.uk/pdbsum/4qla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qla ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Microsomal_epoxide_hydrolase Microsomal epoxide hydrolase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.9 3.3.2.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qla OCA], [https://pdbe.org/4qla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qla RCSB], [https://www.ebi.ac.uk/pdbsum/4qla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qla ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The juvenile hormone (JH) epoxide hydrolase (JHEH) catalyzes the degradation of JH, which regulates the metamorphosis development of insects. Here we report the 2.30 A crystal structure of JHEH from the silkworm Bombyx mori (BmJHEH). The overall structure of BmJHEH is composed of an N-terminal segment followed by a core hydrolase domain, which is interrupted by an all-alpha lid domain. Structural analyses together with molecular simulation reveal insights into the conservation and specificity of the active-site pocket. These findings increase our understanding of the substrate recognition and catalysis of microsomal epoxide hydrolase family and might help the design of JH-derived pesticides. (c) Proteins 2014;. (c) 2014 Wiley Periodicals, Inc.
Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori.,Zhou K, Jia N, Hu C, Jiang YL, Yang JP, Chen Y, Li S, Li WF, Zhou CZ Proteins. 2014 Aug 21. doi: 10.1002/prot.24676. PMID:25143157<ref>PMID:25143157</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 4qla" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Epoxide hydrolase 3D structures|Epoxide hydrolase 3D structures]]
*[[Epoxide hydrolase 3D structures|Epoxide hydrolase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Microsomal epoxide hydrolase]]
[[Category: Chen Y]]
[[Category: Chen, Y]]
[[Category: Hu C]]
[[Category: Hu, C]]
[[Category: Jia N]]
[[Category: Jia, N]]
[[Category: Jiang YL]]
[[Category: Jiang, Y L]]
[[Category: Li S]]
[[Category: Li, S]]
[[Category: Yang JP]]
[[Category: Yang, J P]]
[[Category: Zhou CZ]]
[[Category: Zhou, C Z]]
[[Category: Zhou K]]
[[Category: Zhou, K]]
[[Category: Alpha/beta hydrolase]]
[[Category: Epoxide hydrolase]]
[[Category: Hydrolase]]

Revision as of 10:55, 31 August 2022

Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori

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