4ae8: Difference between revisions
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<StructureSection load='4ae8' size='340' side='right'caption='[[4ae8]], [[Resolution|resolution]] 1.59Å' scene=''> | <StructureSection load='4ae8' size='340' side='right'caption='[[4ae8]], [[Resolution|resolution]] 1.59Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ae8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4ae8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AE8 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ae8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ae8 OCA], [https://pdbe.org/4ae8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ae8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ae8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ae8 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.594Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ae8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ae8 OCA], [https://pdbe.org/4ae8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ae8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ae8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ae8 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/THEM4_HUMAN THEM4_HUMAN] Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.<ref>PMID:11598301</ref> <ref>PMID:17615157</ref> <ref>PMID:19453107</ref> <ref>PMID:19168129</ref> <ref>PMID:19421406</ref> <ref>PMID:22871024</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bleck | [[Category: Bleck CKE]] | ||
[[Category: Cron | [[Category: Cron P]] | ||
[[Category: | [[Category: Degli Esposti M]] | ||
[[Category: | [[Category: Dummler B]] | ||
[[Category: Genoud | [[Category: Genoud C]] | ||
[[Category: Gut | [[Category: Gut H]] | ||
[[Category: Hemmings | [[Category: Hemmings BA]] | ||
[[Category: Hynx | [[Category: Hynx D]] | ||
[[Category: Keusch | [[Category: Keusch JJ]] | ||
[[Category: Marcellin | [[Category: Marcellin D]] | ||
[[Category: Zhuravleva | [[Category: Zhuravleva E]] | ||
