4ael: Difference between revisions
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<StructureSection load='4ael' size='340' side='right'caption='[[4ael]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='4ael' size='340' side='right'caption='[[4ael]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4ael]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AEL FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HN:2-(2-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE'>4HN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HN:2-(2-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE'>4HN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ael FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ael OCA], [https://pdbe.org/4ael PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ael RCSB], [https://www.ebi.ac.uk/pdbsum/4ael PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ael ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ael FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ael OCA], [https://pdbe.org/4ael PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ael RCSB], [https://www.ebi.ac.uk/pdbsum/4ael PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ael ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bauer | [[Category: Bauer M]] | ||
[[Category: Bauer | [[Category: Bauer U]] | ||
[[Category: Enroth C]] | |||
[[Category: Enroth | [[Category: Giordanetto F]] | ||
[[Category: Giordanetto | [[Category: Hartleib-Geschwindner J]] | ||
[[Category: Hartleib-Geschwindner | [[Category: Johansson KE]] | ||
[[Category: Johansson | [[Category: Knecht W]] | ||
[[Category: Knecht | [[Category: OMahony G]] | ||
[[Category: OMahony | [[Category: Sjogren T]] | ||
[[Category: Sjogren | [[Category: Toppner Carlsson E]] | ||
[[Category: | |||
Latest revision as of 11:25, 20 December 2023
PDE10A in complex with the inhibitor AZ5
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