4as4: Difference between revisions

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<StructureSection load='4as4' size='340' side='right'caption='[[4as4]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='4as4' size='340' side='right'caption='[[4as4]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4as4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AS4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4as4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AS4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AS4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1awb|1awb]], [[1ima|1ima]], [[1imb|1imb]], [[1imc|1imc]], [[1imd|1imd]], [[1ime|1ime]], [[1imf|1imf]], [[2hhm|2hhm]], [[4as5|4as5]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4as4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4as4 OCA], [https://pdbe.org/4as4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4as4 RCSB], [https://www.ebi.ac.uk/pdbsum/4as4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4as4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4as4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4as4 OCA], [https://pdbe.org/4as4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4as4 RCSB], [https://www.ebi.ac.uk/pdbsum/4as4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4as4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/IMPA1_HUMAN IMPA1_HUMAN]] Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.<ref>PMID:17068342</ref>
[https://www.uniprot.org/uniprot/IMPA1_HUMAN IMPA1_HUMAN] Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.<ref>PMID:17068342</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Inositol-phosphate phosphatase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Churchill, G C]]
[[Category: Churchill GC]]
[[Category: Halliday, A C]]
[[Category: Halliday AC]]
[[Category: Knight, M]]
[[Category: Knight M]]
[[Category: Lack, N A]]
[[Category: Lack NA]]
[[Category: Lowe, E D]]
[[Category: Lowe ED]]
[[Category: Singh, N]]
[[Category: Singh N]]
[[Category: Bipolar disorder]]
[[Category: Hydrolase]]
[[Category: Lithium]]

Latest revision as of 11:34, 20 December 2023

Structure of human inositol monophosphatase 1

4as4, resolution 1.70Å

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