7ysh: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The entry ~~7ysh is ON HOLD~~

==Cryo-EM Structure of FGF23-FGFR1c-aKlotho-HS Quaternary Complex==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[7ysh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YSH FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ysh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ysh OCA], [https://pdbe.org/7ysh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ysh RCSB], [https://www.ebi.ac.uk/pdbsum/7ysh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ysh ProSAT]</span></td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/KLOT_HUMAN KLOT_HUMAN] Familial tumoral calcinosis. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[https://www.uniprot.org/uniprot/KLOT_HUMAN KLOT_HUMAN] May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Chen L]]

[[Category: Mohammadi M]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7ysh is ON HOLD
+==Cryo-EM Structure of FGF23-FGFR1c-aKlotho-HS Quaternary Complex==
+<StructureSection load='7ysh' size='340' side='right'caption='[[7ysh]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7ysh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YSH FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ysh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ysh OCA], [https://pdbe.org/7ysh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ysh RCSB], [https://www.ebi.ac.uk/pdbsum/7ysh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ysh ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/KLOT_HUMAN KLOT_HUMAN] Familial tumoral calcinosis. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/KLOT_HUMAN KLOT_HUMAN] May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).  The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chen L]]
+[[Category: Mohammadi M]]