7yuk: Difference between revisions
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==Complex structure of BANP BEN domain bound to DNA== | |||
<StructureSection load='7yuk' size='340' side='right'caption='[[7yuk]], [[Resolution|resolution]] 2.11Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7yuk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YUK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YUK FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yuk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yuk OCA], [https://pdbe.org/7yuk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yuk RCSB], [https://www.ebi.ac.uk/pdbsum/7yuk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yuk ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Chen | == Function == | ||
[[Category: Min | [https://www.uniprot.org/uniprot/BANP_HUMAN BANP_HUMAN] Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 activation, which causes cell cycle arrest (By similarity).[UniProtKB:Q8VBU8]<ref>PMID:16166625</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Chen YX]] | |||
[[Category: Liu K]] | |||
[[Category: Min JR]] | |||
[[Category: Xiao YQ]] | |||
[[Category: Zhang J]] | |||
Revision as of 17:00, 26 April 2023
Complex structure of BANP BEN domain bound to DNA
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