1i1j: Difference between revisions

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[[Image:1i1j.gif|left|200px]]
{{Seed}}
[[Image:1i1j.png|left|200px]]


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{{STRUCTURE_1i1j|  PDB=1i1j  |  SCENE=  }}  
{{STRUCTURE_1i1j|  PDB=1i1j  |  SCENE=  }}  


'''STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN: A MEMBER OF A NEW FAMILY OF SECRETED PROTEINS'''
===STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN: A MEMBER OF A NEW FAMILY OF SECRETED PROTEINS===




==Overview==
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Melanoma inhibitory activity (MIA) is a 12-kDa protein that is secreted from both chondrocytes and malignant melanoma cells. MIA has been reported to have effects on cell growth and adhesion, and it may play a role in melanoma metastasis and cartilage development. We report the 1.4-A crystal structure of human MIA, which consists of an Src homology 3 (SH3)-like domain with N- and C-terminal extensions of about 20 aa. each. The N- and C-terminal extensions add additional structural elements to the SH3 domain, forming a previously undescribed fold. MIA is a representative of a recently identified family of proteins and is the first structure of a secreted protein with an SH3 subdomain. The structure also suggests a likely protein interaction site and suggests that, unlike conventional SH3 domains, MIA does not recognize polyproline helices.
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{{ABSTRACT_PUBMED_11331761}}


==About this Structure==
==About this Structure==
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[[Category: Lougheed, J C.]]
[[Category: Lougheed, J C.]]
[[Category: Sh3 subdomain]]
[[Category: Sh3 subdomain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:16:37 2008''

Revision as of 07:16, 1 July 2008

File:1i1j.png

Template:STRUCTURE 1i1j

STRUCTURE OF MELANOMA INHIBITORY ACTIVITY PROTEIN: A MEMBER OF A NEW FAMILY OF SECRETED PROTEINS

Template:ABSTRACT PUBMED 11331761

About this Structure

1I1J is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins., Lougheed JC, Holton JM, Alber T, Bazan JF, Handel TM, Proc Natl Acad Sci U S A. 2001 May 8;98(10):5515-20. Epub 2001 May 1. PMID:11331761

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