7mwh: Difference between revisions
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==== | ==Crystal structure of BAZ2A with DNA== | ||
<StructureSection load='7mwh' size='340' side='right'caption='[[7mwh]]' scene=''> | <StructureSection load='7mwh' size='340' side='right'caption='[[7mwh]], [[Resolution|resolution]] 2.28Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7mwh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MWH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MWH FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mwh OCA], [https://pdbe.org/7mwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mwh RCSB], [https://www.ebi.ac.uk/pdbsum/7mwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mwh ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mwh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mwh OCA], [https://pdbe.org/7mwh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mwh RCSB], [https://www.ebi.ac.uk/pdbsum/7mwh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mwh ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN]] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: Arrowsmith CH]] | |||
[[Category: Dong A]] | |||
[[Category: Edwards AM]] | |||
[[Category: Li Y]] | |||
[[Category: Liu K]] | |||
[[Category: Loppnau P]] | |||
[[Category: Min J]] | |||
