4b6h: Difference between revisions

<table><tr><td colspan='2'>[[4b6h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4B6H FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4b6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b6h OCA], [https://pdbe.org/4b6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4b6h RCSB], [https://www.ebi.ac.uk/pdbsum/4b6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4b6h ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/DCP1A_HUMAN DCP1A_HUMAN]] Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.<ref>PMID:11836524</ref> <ref>PMID:12417715</ref> [[https://www.uniprot.org/uniprot/PNRC2_HUMAN PNRC2_HUMAN]] Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure.<ref>PMID:11574675</ref> <ref>PMID:19150429</ref> 

[[Category: Human]]

[[Category: Lai, T]]

[[Category: Song, H]]

[[Category: Hydrolase-peptide complex]]