4boq: Difference between revisions

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<StructureSection load='4boq' size='340' side='right'caption='[[4boq]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
<StructureSection load='4boq' size='340' side='right'caption='[[4boq]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4boq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BOQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4boq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BOQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4bop|4bop]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4boq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4boq OCA], [https://pdbe.org/4boq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4boq RCSB], [https://www.ebi.ac.uk/pdbsum/4boq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4boq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4boq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4boq OCA], [https://pdbe.org/4boq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4boq RCSB], [https://www.ebi.ac.uk/pdbsum/4boq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4boq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/OTU1_HUMAN OTU1_HUMAN]] Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Able to cleave both polyubiquitin and di-ubiquitin.  
[https://www.uniprot.org/uniprot/OTU1_HUMAN OTU1_HUMAN] Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Able to cleave both polyubiquitin and di-ubiquitin.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ubiquitinyl hydrolase 1]]
[[Category: Akutsu M]]
[[Category: Akutsu, M]]
[[Category: Arnaudo N]]
[[Category: Arnaudo, N]]
[[Category: Ekkebus R]]
[[Category: Ekkebus, R]]
[[Category: El Oualid F]]
[[Category: Elliott, P R]]
[[Category: Elliott PR]]
[[Category: Freund, S M.V]]
[[Category: Freund SMV]]
[[Category: Geurink, P P]]
[[Category: Geurink PP]]
[[Category: Hospenthal, M K]]
[[Category: Hospenthal MK]]
[[Category: Komander, D]]
[[Category: Komander D]]
[[Category: Kulathu, Y]]
[[Category: Kulathu Y]]
[[Category: Mevissen, T E.T]]
[[Category: Mevissen TET]]
[[Category: Oualid, F El]]
[[Category: Ovaa H]]
[[Category: Ovaa, H]]
[[Category: Wauer T]]
[[Category: Wauer, T]]
[[Category: Hydrolase]]
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