2n84: Difference between revisions
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<StructureSection load='2n84' size='340' side='right'caption='[[2n84]]' scene=''> | <StructureSection load='2n84' size='340' side='right'caption='[[2n84]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full | <table><tr><td colspan='2'>[[2n84]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N84 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n84 OCA], [https://pdbe.org/2n84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n84 RCSB], [https://www.ebi.ac.uk/pdbsum/2n84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n84 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n84 OCA], [https://pdbe.org/2n84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n84 RCSB], [https://www.ebi.ac.uk/pdbsum/2n84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n84 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q57XM6_TRYB2 Q57XM6_TRYB2] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Trypanosoma brucei is a unicellular eukaryotic parasite, which causes the African sleeping sickness in humans. The recently discovered trypanosomal protein Parvulin 42 (TbPar42) plays a key role in parasite cell proliferation. Homologues of this two-domain protein are exclusively found in protozoa species. TbPar42 exhibits an N-terminal forkhead associated (FHA)-domain and a peptidyl-prolyl-cis/trans-isomerase (PPIase) domain, both connected by a linker. Using NMR and X-ray analysis as well as activity assays, we report on the structures of the single domains of TbPar42, discuss their intra-molecular interplay, and give some initial hints as to potential cellular functions of the protein. | |||
Structural Analysis of the 42 kDa Parvulin of Trypanosoma brucei.,Rehic E, Hoenig D, Kamba BE, Goehring A, Hofmann E, Gasper R, Matena A, Bayer P Biomolecules. 2019 Mar 7;9(3). pii: biom9030093. doi: 10.3390/biom9030093. PMID:30866577<ref>PMID:30866577</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2n84" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Trypanosoma brucei brucei TREU927]] | |||
[[Category: Bayer P]] | [[Category: Bayer P]] | ||
[[Category: Rehic E]] | [[Category: Rehic E]] | ||
Latest revision as of 09:57, 14 June 2023
Solution structure of the FHA domain of TbPar42
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