1i42: Difference between revisions

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[[Image:1i42.~~gif~~|left|200px]]

[[Image:1i42.png|left|200px]]

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~~'''~~NMR STRUCTURE OF THE UBX DOMAIN FROM P47~~'''~~

===NMR STRUCTURE OF THE UBX DOMAIN FROM P47===

~~==Overview==~~

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~~p47 is~~ the ~~major protein identified in complex with~~ the ~~cytosolic AAA ATPase p97~~. ~~It functions as an essential cofactor of p97-regulated membrane fusion, which has been suggested to disassemble t-t-SNARE complexes and prepare them for further rounds of membrane fusion~~. ~~Here~~, ~~we report the high-resolution NMR structure of~~ the ~~C-terminal domain from p47~~. ~~It comprises a UBX domain and a 13 residue long structured N~~-~~terminal extension. The UBX domain adopts a characteristic ubiquitin fold with a betabetaalphabetabetaalphabeta secondary structure arrangement. Three hydrophobic residues from the N~~-~~terminal extension pack closely against a cleft in the UBX domain. We also identify, for the first time, the p97 interaction surface using NMR chemical shift perturbation studies.~~

The line below this paragraph, {{ABSTRACT_PUBMED_11478859}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11478859 is the PubMed ID number.

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==About this Structure==

1I42 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I42 OCA].

1I42 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I42 OCA].

==Reference==

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[[Category: Ubx]]

[[Category: Unusual n-terminal feature]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 19~~:32:46 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:23:04 2008''

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-[[Image:1i42.gif|left|200px]]
+{{Seed}}
+[[Image:1i42.png|left|200px]]
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 {{STRUCTURE_1i42|  PDB=1i42  |  SCENE=  }}
-'''NMR STRUCTURE OF THE UBX DOMAIN FROM P47'''
+===NMR STRUCTURE OF THE UBX DOMAIN FROM P47===
-==Overview==
+<!--
-p47 is the major protein identified in complex with the cytosolic AAA ATPase p97. It functions as an essential cofactor of p97-regulated membrane fusion, which has been suggested to disassemble t-t-SNARE complexes and prepare them for further rounds of membrane fusion. Here, we report the high-resolution NMR structure of the C-terminal domain from p47. It comprises a UBX domain and a 13 residue long structured N-terminal extension. The UBX domain adopts a characteristic ubiquitin fold with a betabetaalphabetabetaalphabeta secondary structure arrangement. Three hydrophobic residues from the N-terminal extension pack closely against a cleft in the UBX domain. We also identify, for the first time, the p97 interaction surface using NMR chemical shift perturbation studies.
+The line below this paragraph, {{ABSTRACT_PUBMED_11478859}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11478859 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11478859}}
 ==About this Structure==
-I42 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I42 OCA].
+I42 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I42 OCA].
 ==Reference==
@@ Line 32: / Line 36: @@
 [[Category: Ubx]]
 [[Category: Unusual n-terminal feature]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:32:46 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 10:23:04 2008''