4q2k: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Bovine alpha chymotrypsin bound to a cyclic peptide inhibitor, 5b== | ==Bovine alpha chymotrypsin bound to a cyclic peptide inhibitor, 5b== | ||
<StructureSection load='4q2k' size='340' side='right'caption='[[4q2k]]' scene=''> | <StructureSection load='4q2k' size='340' side='right'caption='[[4q2k]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q2K FirstGlance]. <br> | <table><tr><td colspan='2'>[[4q2k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q2K FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q2k OCA], [https://pdbe.org/4q2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q2k RCSB], [https://www.ebi.ac.uk/pdbsum/4q2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q2k ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5BF:(11S)-4,9-DIOXO-N-[(2S)-1-OXO-3-PHENYLPROPAN-2-YL]-17,22-DIOXA-10,30-DIAZATETRACYCLO[21.2.2.2~13,16~.1~5,8~]TRIACONTA-1(25),5,7,13,15,23,26,28-OCTAENE-11-CARBOXAMIDE'>5BF</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q2k OCA], [https://pdbe.org/4q2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q2k RCSB], [https://www.ebi.ac.uk/pdbsum/4q2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q2k ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CTRA_BOVIN CTRA_BOVIN] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
There is a real need for simple structures that define a beta-strand conformation, a secondary structure that is central to peptide-protein interactions. For example, protease substrates and inhibitors almost universally adopt this geometry on active site binding. A planar pyrrole is used to replace two amino acids of a peptide backbone to generate a simple macrocycle that retains the required geometry for active site binding. The resulting beta-strand templates have reduced peptide character and provide potent protease inhibitors with the attachment of an appropriate amino aldehyde to the C-terminus. Picomolar inhibitors of cathepsin L and S are reported and the mode of binding of one example to the model protease chymotrypsin is defined by X-ray crystallography. | |||
Macrocyclic protease inhibitors with reduced Peptide character.,Chua KC, Pietsch M, Zhang X, Hautmann S, Chan HY, Bruning JB, Gutschow M, Abell AD Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7828-31. doi: 10.1002/anie.201404301. , Epub 2014 Jun 5. PMID:24903745<ref>PMID:24903745</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 4q2k" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Chymotrypsin 3D structures|Chymotrypsin 3D structures]] | *[[Chymotrypsin 3D structures|Chymotrypsin 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bos taurus]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Abell AD]] | [[Category: Abell AD]] | ||
[[Category: Bruning JB]] | [[Category: Bruning JB]] | ||
[[Category: Chan HY]] | [[Category: Chan HY]] | ||
