1i47: Difference between revisions

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[[Image:1i47.~~gif~~|left|200px]]

[[Image:1i47.png|left|200px]]

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~~'''~~MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGAATT(MO4)CGCG): THE WATSON-CRICK TYPE AND WOBBLE N4-METHOXYCYTIDINE/GUANOSINE BASE PAIRS IN B-DNA~~'''~~

===MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGAATT(MO4)CGCG): THE WATSON-CRICK TYPE AND WOBBLE N4-METHOXYCYTIDINE/GUANOSINE BASE PAIRS IN B-DNA===

~~==Overview==~~

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~~To investigate~~ the ~~mutation mechanism of purine transition in DNA damaged with methoxyamine, a DNA dodecamer with~~ the ~~sequence d~~(~~CGCGAATTmo(4)CGCG~~), where ~~mo(4)C~~ is ~~2'-deoxy-N(4)-methoxycytidine, has been synthesized and its crystal structure determined~~. ~~Two dodecamers form a B~~-~~form duplex. Electron density maps clearly show that one of the two mo(4)C residues forms a pair with a guanine residue of the opposite strand, the geometry being the canonical Watson~~-Crick type, and that the other mo(4)C residue forms a wobble pair with the opposite guanine residue. These two pairings are ascribed to the tautomerization of the methoxylated cytosine moieties between the amino and imino forms.

The line below this paragraph, {{ABSTRACT_PUBMED_11432773}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11432773 is the PubMed ID number.

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==About this Structure==

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[[Category: Double helix]]

[[Category: N4-methoxycytosine]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 19~~:33:09 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:23:30 2008''

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-[[Image:1i47.gif|left|200px]]
+{{Seed}}
+[[Image:1i47.png|left|200px]]
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 {{STRUCTURE_1i47|  PDB=1i47  |  SCENE=  }}
-'''MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGAATT(MO4)CGCG): THE WATSON-CRICK TYPE AND WOBBLE N4-METHOXYCYTIDINE/GUANOSINE BASE PAIRS IN B-DNA'''
+===MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGAATT(MO4)CGCG): THE WATSON-CRICK TYPE AND WOBBLE N4-METHOXYCYTIDINE/GUANOSINE BASE PAIRS IN B-DNA===
-==Overview==
+<!--
-To investigate the mutation mechanism of purine transition in DNA damaged with methoxyamine, a DNA dodecamer with the sequence d(CGCGAATTmo(4)CGCG), where mo(4)C is 2'-deoxy-N(4)-methoxycytidine, has been synthesized and its crystal structure determined. Two dodecamers form a B-form duplex. Electron density maps clearly show that one of the two mo(4)C residues forms a pair with a guanine residue of the opposite strand, the geometry being the canonical Watson-Crick type, and that the other mo(4)C residue forms a wobble pair with the opposite guanine residue. These two pairings are ascribed to the tautomerization of the methoxylated cytosine moieties between the amino and imino forms.
+The line below this paragraph, {{ABSTRACT_PUBMED_11432773}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11432773 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11432773}}
 ==About this Structure==
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 [[Category: Double helix]]
 [[Category: N4-methoxycytosine]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:33:09 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 10:23:30 2008''