1i4f: Difference between revisions

Line 1:

[[Image:1i4f.~~gif~~|left|200px]]

[[Image:1i4f.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~CRYSTAL STRUCTURE OF HLA-A*0201/MAGE-A4-PEPTIDE COMPLEX~~'''~~

===CRYSTAL STRUCTURE OF HLA-A*0201/MAGE-A4-PEPTIDE COMPLEX===

~~==Overview==~~

<!--

The ~~heterotrimeric complex of the human major histocompatibity complex (MHC) molecule HLA-A*0201~~, ~~beta2-microglobulin and~~ the ~~decameric peptide GVYDGREHTV derived from~~ the ~~melanoma antigen~~ (~~MAGE-A4 protein has been determined by X-ray crystallography~~ at 1.~~4 A resolution~~. ~~MAGE-A4 belongs to a family of genes that are specifically expressed in a variety of tumours. MAGE-A4-derived peptides are presented by MHC molecules at~~ the ~~cell surface to cytotoxic T-lymphocytes~~. ~~As the HLA~~-~~A*0201:MAGE~~-A4 complex occurs only on tumour cells, it is considered to be an appropriate target for immunotherapy. The structure presented here reveals potential epitopes specific to the complex and indicates which peptide residues could be recognised by T-cell receptors. In addition, as the structure could be refined anisotropically, it was possible to describe the movements of the bound peptide in more detail.

The line below this paragraph, {{ABSTRACT_PUBMED_11502003}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11502003 is the PubMed ID number.

-->

==Disease==

Line 34:

Line 38:

[[Category: Major histocompatibility complex]]

[[Category: Melanoma-associated antigen]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 19~~:33:38 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:24:06 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1i4f.gif|left|200px]]
+{{Seed}}
+[[Image:1i4f.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1i4f|  PDB=1i4f  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF HLA-A*0201/MAGE-A4-PEPTIDE COMPLEX'''
+===CRYSTAL STRUCTURE OF HLA-A*0201/MAGE-A4-PEPTIDE COMPLEX===
-==Overview==
+<!--
-The heterotrimeric complex of the human major histocompatibity complex (MHC) molecule HLA-A*0201, beta2-microglobulin and the decameric peptide GVYDGREHTV derived from the melanoma antigen (MAGE-A4 protein has been determined by X-ray crystallography at 1.4 A resolution. MAGE-A4 belongs to a family of genes that are specifically expressed in a variety of tumours. MAGE-A4-derived peptides are presented by MHC molecules at the cell surface to cytotoxic T-lymphocytes. As the HLA-A*0201:MAGE-A4 complex occurs only on tumour cells, it is considered to be an appropriate target for immunotherapy. The structure presented here reveals potential epitopes specific to the complex and indicates which peptide residues could be recognised by T-cell receptors. In addition, as the structure could be refined anisotropically, it was possible to describe the movements of the bound peptide in more detail.
+The line below this paragraph, {{ABSTRACT_PUBMED_11502003}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11502003 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11502003}}
 ==Disease==
@@ Line 34: / Line 38: @@
 [[Category: Major histocompatibility complex]]
 [[Category: Melanoma-associated antigen]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:33:38 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 10:24:06 2008''