8ecg: Difference between revisions

Revision as of 06:59, 14 September 2022

Complex of HMG1 with pitavastatin

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[1] Suzuki M, Kamide Y, Nagata N, Seki H, Ohyama K, Kato H, Masuda K, Sato S, Kato T, Tabata S, Yoshida S, Muranaka T. Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels. Plant J. 2004 Mar;37(5):750-61. doi: 10.1111/j.1365-313x.2004.02003.x. PMID:14871314 doi:https://dx.doi.org/10.1111/j.1365-313x.2004.02003.x

[2] Ohyama K, Suzuki M, Masuda K, Yoshida S, Muranaka T. Chemical phenotypes of the hmg1 and hmg2 mutants of Arabidopsis demonstrate the in-planta role of HMG-CoA reductase in triterpene biosynthesis. Chem Pharm Bull (Tokyo). 2007 Oct;55(10):1518-21. doi: 10.1248/cpb.55.1518. PMID:17917299 doi:https://dx.doi.org/10.1248/cpb.55.1518

[3] Nieto B, Fores O, Arro M, Ferrer A. Arabidopsis 3-hydroxy-3-methylglutaryl-CoA reductase is regulated at the post-translational level in response to alterations of the sphingolipid and the sterol biosynthetic pathways. Phytochemistry. 2009 Jan;70(1):53-9. doi: 10.1016/j.phytochem.2008.10.010. Epub, 2008 Nov 27. PMID:19041104 doi:https://dx.doi.org/10.1016/j.phytochem.2008.10.010

[4] Suzuki M, Nakagawa S, Kamide Y, Kobayashi K, Ohyama K, Hashinokuchi H, Kiuchi R, Saito K, Muranaka T, Nagata N. Complete blockage of the mevalonate pathway results in male gametophyte lethality. J Exp Bot. 2009;60(7):2055-64. doi: 10.1093/jxb/erp073. Epub 2009 Apr 10. PMID:19363204 doi:https://dx.doi.org/10.1093/jxb/erp073

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-'''Unreleased structure'''
-The entry 8ecg is ON HOLD
+==Complex of HMG1 with pitavastatin==
+<StructureSection load='8ecg' size='340' side='right'caption='[[8ecg]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8ecg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ECG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ECG FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PV9:Pitavastatin'>PV9</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ecg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ecg OCA], [https://pdbe.org/8ecg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ecg RCSB], [https://www.ebi.ac.uk/pdbsum/8ecg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ecg ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[https://www.uniprot.org/uniprot/HMDH1_ARATH HMDH1_ARATH]] Catalyzes the synthesis of mevalonate, the specific precursor of all isoprenoid compounds present in plants.<ref>PMID:14871314</ref> <ref>PMID:17917299</ref> <ref>PMID:19041104</ref> <ref>PMID:19363204</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Arabidopsis thaliana]]
+[[Category: Large Structures]]
+[[Category: Bond CS]]
+[[Category: Haywood J]]

8ecg: Difference between revisions

Revision as of 06:59, 14 September 2022

Complex of HMG1 with pitavastatin

Structural highlights

Function

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