8gnk: Difference between revisions

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'''Unreleased structure'''


The entry 8gnk is ON HOLD  until Paper Publication
==CryoEM structure of cytosol-facing, substrate-bound ratGAT1==
 
<StructureSection load='8gnk' size='340' side='right'caption='[[8gnk]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8gnk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GNK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GNK FirstGlance]. <br>
Description:  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gnk OCA], [https://pdbe.org/8gnk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gnk RCSB], [https://www.ebi.ac.uk/pdbsum/8gnk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gnk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SC6A1_RAT SC6A1_RAT] Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:1975955, PubMed:18054861). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (PubMed:18054861, PubMed:21775701). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (PubMed:18054861, PubMed:21775701). Also mediates sodium- and chloride-dependent transport of hypotaurine (By similarity).[UniProtKB:P31648]<ref>PMID:18054861</ref> <ref>PMID:1975955</ref> <ref>PMID:21775701</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Rattus norvegicus]]
[[Category: Joseph D]]
[[Category: Nayak SR]]
[[Category: Penmatsa A]]
Retrieved from "https://proteopedia.org/8gnk"