1gen: Difference between revisions
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caption="1gen, resolution 2.15Å" /> | caption="1gen, resolution 2.15Å" /> | ||
'''C-TERMINAL DOMAIN OF GELATINASE A'''<br /> | '''C-TERMINAL DOMAIN OF GELATINASE A'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structure of the haemopexin-like C-terminal domain of | The crystal structure of the haemopexin-like C-terminal domain of gelatinase A reveals that it is a four-bladed beta-propeller protein. The four blades are arranged around a channel-like opening in which Ca2+ and a Na-Cl+ ion pair are bound. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1GEN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, CA, CL and NA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24] Full crystallographic information is available from [http:// | 1GEN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GEN OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Collier, I | [[Category: Collier, I E.]] | ||
[[Category: Gittis, A | [[Category: Gittis, A G.]] | ||
[[Category: Goldberg, G | [[Category: Goldberg, G G.]] | ||
[[Category: Lattman, E | [[Category: Lattman, E E.]] | ||
[[Category: Libson, A | [[Category: Libson, A M.]] | ||
[[Category: Marmer, B | [[Category: Marmer, B L.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
[[Category: CL]] | [[Category: CL]] | ||
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[[Category: metalloprotease]] | [[Category: metalloprotease]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:49:13 2008'' | ||
Revision as of 10:49, 21 February 2008
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C-TERMINAL DOMAIN OF GELATINASE A
Overview
The crystal structure of the haemopexin-like C-terminal domain of gelatinase A reveals that it is a four-bladed beta-propeller protein. The four blades are arranged around a channel-like opening in which Ca2+ and a Na-Cl+ ion pair are bound.
Disease
Known diseases associated with this structure: Osteolysis, idiopathic, Saudi type OMIM:[120360], Winchester syndrome OMIM:[120360]
About this Structure
1GEN is a Single protein structure of sequence from Homo sapiens with ZN, CA, CL and NA as ligands. Active as Gelatinase A, with EC number 3.4.24.24 Full crystallographic information is available from OCA.
Reference
Crystal structure of the haemopexin-like C-terminal domain of gelatinase A., Libson AM, Gittis AG, Collier IE, Marmer BL, Goldberg GI, Lattman EE, Nat Struct Biol. 1995 Nov;2(11):938-42. PMID:7583664
Page seeded by OCA on Thu Feb 21 12:49:13 2008
