1i6v: Difference between revisions

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No edit summary
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[[Image:1i6v.gif|left|200px]]
{{Seed}}
[[Image:1i6v.png|left|200px]]


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{{STRUCTURE_1i6v|  PDB=1i6v  |  SCENE=  }}  
{{STRUCTURE_1i6v|  PDB=1i6v  |  SCENE=  }}  


'''THERMUS AQUATICUS CORE RNA POLYMERASE-RIFAMPICIN COMPLEX'''
===THERMUS AQUATICUS CORE RNA POLYMERASE-RIFAMPICIN COMPLEX===




==Overview==
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Rifampicin (Rif) is one of the most potent and broad spectrum antibiotics against bacterial pathogens and is a key component of anti-tuberculosis therapy, stemming from its inhibition of the bacterial RNA polymerase (RNAP). We determined the crystal structure of Thermus aquaticus core RNAP complexed with Rif. The inhibitor binds in a pocket of the RNAP beta subunit deep within the DNA/RNA channel, but more than 12 A away from the active site. The structure, combined with biochemical results, explains the effects of Rif on RNAP function and indicates that the inhibitor acts by directly blocking the path of the elongating RNA when the transcript becomes 2 to 3 nt in length.
The line below this paragraph, {{ABSTRACT_PUBMED_11290327}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11290327 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11290327}}


==About this Structure==
==About this Structure==
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:38:35 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:30:20 2008''
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