1i8t: Difference between revisions

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[[Image:1i8t.jpg|left|200px]]
{{Seed}}
[[Image:1i8t.png|left|200px]]


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{{STRUCTURE_1i8t|  PDB=1i8t  |  SCENE=  }}  
{{STRUCTURE_1i8t|  PDB=1i8t  |  SCENE=  }}  


'''STRCUTURE OF UDP-GALACTOPYRANOSE MUTASE FROM E.COLI'''
===STRCUTURE OF UDP-GALACTOPYRANOSE MUTASE FROM E.COLI===




==Overview==
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Uridine diphosphogalactofuranose (UDP-Galf ) is the precursor of the d-galactofuranose (Galf ) residues found in bacterial and parasitic cell walls, including those of many pathogens, such as Mycobacterium tuberculosis and Trypanosoma cruzi. UDP-Galf is made from UDP-galactopyranose (UDP-Galp) by the enzyme UDP-galactopyranose mutase (mutase). The mutase enzyme is essential for the viability of mycobacteria and is not found in humans, making it a viable therapeutic target. The mechanism by which mutase achieves the unprecedented ring contraction of a nonreducing sugar is unclear. We have solved the crystal structure of Escherichia coli mutase to 2.4 A resolution. The novel structure shows that the flavin nucleotide is located in a cleft lined with conserved residues. Site-directed mutagenesis studies indicate that this cleft contains the active site, with the sugar ring of the substrate UDP-galactose adjacent to the exposed isoalloxazine ring of FAD. Assay results establish that the enzyme is active only when flavin is reduced. We conclude that mutase most likely functions by transient reduction of substrate.
The line below this paragraph, {{ABSTRACT_PUBMED_11573090}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11573090 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11573090}}


==About this Structure==
==About this Structure==
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[[Category: Rossman fold]]
[[Category: Rossman fold]]
[[Category: Udp-galactopyranose]]
[[Category: Udp-galactopyranose]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:42:59 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:35:51 2008''

Revision as of 07:35, 1 July 2008

File:1i8t.png

Template:STRUCTURE 1i8t

STRCUTURE OF UDP-GALACTOPYRANOSE MUTASE FROM E.COLI

Template:ABSTRACT PUBMED 11573090

About this Structure

1I8T is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

UDP-galactopyranose mutase has a novel structure and mechanism., Sanders DA, Staines AG, McMahon SA, McNeil MR, Whitfield C, Naismith JH, Nat Struct Biol. 2001 Oct;8(10):858-63. PMID:11573090

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