8ag2: Difference between revisions
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. | |||
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</StructureSection> | </StructureSection> | ||
Revision as of 10:03, 15 March 2023
Crystal structure of the BPTF bromodomain in complex with BI-7190
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