1i9y: Difference between revisions

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[[Image:1i9y.jpg|left|200px]]
{{Seed}}
[[Image:1i9y.png|left|200px]]


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{{STRUCTURE_1i9y|  PDB=1i9y  |  SCENE=  }}  
{{STRUCTURE_1i9y|  PDB=1i9y  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 5-PHOSPHATASE DOMAIN (IPP5C) OF SPSYNAPTOJANIN'''
===CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 5-PHOSPHATASE DOMAIN (IPP5C) OF SPSYNAPTOJANIN===




==Overview==
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Inositol polyphosphate 5-phosphatases are central to intracellular processes ranging from membrane trafficking to Ca(2+) signaling, and defects in this activity result in the human disease Lowe syndrome. The 1.8 resolution structure of the inositol polyphosphate 5-phosphatase domain of SPsynaptojanin bound to Ca(2+) and inositol (1,4)-bisphosphate reveals a fold and an active site His and Asp pair resembling those of several Mg(2+)-dependent nucleases. Additional loops mediate specific inositol polyphosphate contacts. The 4-phosphate of inositol (1,4)-bisphosphate is misoriented by 4.6 compared to the reactive geometry observed in the apurinic/apyrimidinic endonuclease 1, explaining the dephosphorylation site selectivity of the 5-phosphatases. Based on the structure, a series of mutants are described that exhibit altered substrate specificity providing general determinants for substrate recognition.
The line below this paragraph, {{ABSTRACT_PUBMED_11348594}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_11348594}}


==About this Structure==
==About this Structure==
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[[Category: Inositol 5-phosphatase]]
[[Category: Inositol 5-phosphatase]]
[[Category: Ipp5c]]
[[Category: Ipp5c]]
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