1ib2: Difference between revisions

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[[Image:1ib2.gif|left|200px]]
{{Seed}}
[[Image:1ib2.png|left|200px]]


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{{STRUCTURE_1ib2|  PDB=1ib2  |  SCENE=  }}  
{{STRUCTURE_1ib2|  PDB=1ib2  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF A PUMILIO-HOMOLOGY DOMAIN'''
===CRYSTAL STRUCTURE OF A PUMILIO-HOMOLOGY DOMAIN===




==Overview==
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Puf proteins regulate translation and mRNA stability by binding sequences in their target RNAs through the Pumilio homology domain (PUM-HD), which is characterized by eight tandem copies of a 36 amino acid motif, the PUM repeat. We have solved the structure of the PUM-HD from human Pumilio1 at 1.9 A resolution. The structure reveals that the eight PUM repeats correspond to eight copies of a single, repeated structural motif. The PUM repeats pack together to form a right-handed superhelix that approximates a half doughnut. The distribution of side chains on the inner and outer faces of this half doughnut suggests that the inner face of the PUM-HD binds RNA while the outer face interacts with proteins such as Nanos, Brain Tumor, and cytoplasmic polyadenylation element binding protein.
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{{ABSTRACT_PUBMED_11336708}}


==About this Structure==
==About this Structure==
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[[Category: Zamore, P D.]]
[[Category: Zamore, P D.]]
[[Category: Pumilio-homology domain,puf motif]]
[[Category: Pumilio-homology domain,puf motif]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:47:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:41:44 2008''

Revision as of 07:41, 1 July 2008

File:1ib2.png

Template:STRUCTURE 1ib2

CRYSTAL STRUCTURE OF A PUMILIO-HOMOLOGY DOMAIN

Template:ABSTRACT PUBMED 11336708

About this Structure

1IB2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a Pumilio homology domain., Wang X, Zamore PD, Hall TM, Mol Cell. 2001 Apr;7(4):855-65. PMID:11336708

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