1ibr: Difference between revisions

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[[Image:1ibr.gif|left|200px]]
{{Seed}}
[[Image:1ibr.png|left|200px]]


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{{STRUCTURE_1ibr|  PDB=1ibr  |  SCENE=  }}  
{{STRUCTURE_1ibr|  PDB=1ibr  |  SCENE=  }}  


'''COMPLEX OF RAN WITH IMPORTIN BETA'''
===COMPLEX OF RAN WITH IMPORTIN BETA===




==Overview==
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Transport receptors of the Importin beta family shuttle between the nucleus and cytoplasm and mediate transport of macromolecules through nuclear pore complexes. They interact specifically with the GTP-binding protein Ran, which in turn regulates their interaction with cargo. Here, we report the three-dimensional structure of a complex between Ran bound to the nonhydrolyzable GTP analog GppNHp and a 462-residue fragment from Importin beta. The structure of Importin beta shows 10 tandem repeats resembling HEAT and Armadillo motifs. They form an irregular crescent, the concave site of which forms the interface with Ran-triphosphate. The importin-binding site of Ran does not overlap with that of the Ran-binding domain of RanBP2.
The line below this paragraph, {{ABSTRACT_PUBMED_10367892}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10367892}}


==About this Structure==
==About this Structure==
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[[Category: Nuclear transport receptor]]
[[Category: Nuclear transport receptor]]
[[Category: Small gtpase]]
[[Category: Small gtpase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:49:07 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:43:41 2008''

Revision as of 07:43, 1 July 2008

File:1ibr.png

Template:STRUCTURE 1ibr

COMPLEX OF RAN WITH IMPORTIN BETA

Template:ABSTRACT PUBMED 10367892

About this Structure

1IBR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural view of the Ran-Importin beta interaction at 2.3 A resolution., Vetter IR, Arndt A, Kutay U, Gorlich D, Wittinghofer A, Cell. 1999 May 28;97(5):635-46. PMID:10367892

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