1ic0: Difference between revisions

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[[Image:1ic0.gif|left|200px]]
{{Seed}}
[[Image:1ic0.png|left|200px]]


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{{STRUCTURE_1ic0|  PDB=1ic0  |  SCENE=  }}  
{{STRUCTURE_1ic0|  PDB=1ic0  |  SCENE=  }}  


'''RED COPPER PROTEIN NITROSOCYANIN FROM NITROSOMONAS EUROPAEA'''
===RED COPPER PROTEIN NITROSOCYANIN FROM NITROSOMONAS EUROPAEA===




==Overview==
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Nitrosocyanin (NC) is a mononuclear red copper protein isolated from the ammonia oxidizing bacterium Nitrosomonas europaea. Although NC exhibits some sequence homology to classic blue copper proteins, its spectroscopic and electrochemical properties are drastically different. The 1.65 A resolution crystal structure of oxidized NC reveals an unprecedented trimer of single domain cupredoxins. Each copper center is partially covered by an unusual extended beta-hairpin structure from an adjacent monomer. The copper ion is coordinated by His 98, His 103, Cys 95, a single side chain oxygen of Glu 60, and a solvent molecule. In the 2.3 A resolution structure of reduced NC, His 98 shifts away from the copper ion, and the solvent molecule is not observed. The arrangement of these ligands renders the coordination geometry of the NC red copper center distinct from that of blue copper centers. In particular, the red copper center has a higher coordination number and lacks the long Cu-S(Met) and short Cu-S(Cys) bond distances characteristic of blue copper. Moreover, the red copper center is square pyramidal whereas blue copper is typically distorted tetrahedral. Analysis of the NC structure provides insight into possible functions of this new type of biological copper center.
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{{ABSTRACT_PUBMED_11341832}}


==About this Structure==
==About this Structure==
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[[Category: Nitrosomonas europaea]]
[[Category: Nitrosomonas europaea]]
[[Category: Red copper]]
[[Category: Red copper]]
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Revision as of 07:44, 1 July 2008

File:1ic0.png

Template:STRUCTURE 1ic0

RED COPPER PROTEIN NITROSOCYANIN FROM NITROSOMONAS EUROPAEA

Template:ABSTRACT PUBMED 11341832

About this Structure

1IC0 is a Single protein structure of sequence from Nitrosomonas europaea. Full crystallographic information is available from OCA.

Reference

Crystal structure of a novel red copper protein from Nitrosomonas europaea., Lieberman RL, Arciero DM, Hooper AB, Rosenzweig AC, Biochemistry. 2001 May 15;40(19):5674-81. PMID:11341832

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