7b5g: Difference between revisions
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/LEXA_ECOLI LEXA_ECOLI] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.<ref>PMID:7027255</ref> <ref>PMID:7027256</ref> | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 06:21, 26 October 2022
Crystal structure of E.coli LexA in complex with nanobody NbSOS3(Nb14527)
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