1if0: Difference between revisions

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~~'''~~PSEUDO-ATOMIC MODEL OF BACTERIOPHAGE HK97 PROCAPSID (PROHEAD II)~~'''~~

===PSEUDO-ATOMIC MODEL OF BACTERIOPHAGE HK97 PROCAPSID (PROHEAD II)===

~~==Overview==~~

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~~Large-scale conformational changes transform viral precursors into infectious virions.~~ The ~~structure of bacteriophage HK97 capsid, Head-II~~, ~~was recently solved by crystallography~~, ~~revealing a catenated cross-linked topology. We have visualized its precursor, Prohead-II, by cryoelectron microscopy and modeled~~ the ~~conformational change by appropriately adapting Head-II. Rigid-body rotations ( approximately 40 degrees) cause switching~~ to ~~an entirely different set of interactions; in addition, two motifs undergo refolding. These changes stabilize~~ the ~~capsid by increasing the surface area buried~~ at ~~interfaces and bringing the cross-link-forming residues, initially approximately 40 angstroms apart~~, ~~close together. The inner surface of Prohead-II~~ is ~~negatively charged, suggesting that~~ the ~~transition is triggered electrostatically by DNA packaging~~.

The line below this paragraph, {{ABSTRACT_PUBMED_11326105}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11326105 is the PubMed ID number.

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==About this Structure==

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[[Category: Pseudo-atomic model.]]

[[Category: Virus]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 19~~:55:47 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 10:52:12 2008''

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-[[Image:1if0.gif|left|200px]]
+{{Seed}}
+[[Image:1if0.png|left|200px]]
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 {{STRUCTURE_1if0|  PDB=1if0  |  SCENE=  }}
-'''PSEUDO-ATOMIC MODEL OF BACTERIOPHAGE HK97 PROCAPSID (PROHEAD II)'''
+===PSEUDO-ATOMIC MODEL OF BACTERIOPHAGE HK97 PROCAPSID (PROHEAD II)===
-==Overview==
+<!--
-Large-scale conformational changes transform viral precursors into infectious virions. The structure of bacteriophage HK97 capsid, Head-II, was recently solved by crystallography, revealing a catenated cross-linked topology. We have visualized its precursor, Prohead-II, by cryoelectron microscopy and modeled the conformational change by appropriately adapting Head-II. Rigid-body rotations ( approximately 40 degrees) cause switching to an entirely different set of interactions; in addition, two motifs undergo refolding. These changes stabilize the capsid by increasing the surface area buried at interfaces and bringing the cross-link-forming residues, initially approximately 40 angstroms apart, close together. The inner surface of Prohead-II is negatively charged, suggesting that the transition is triggered electrostatically by DNA packaging.
+The line below this paragraph, {{ABSTRACT_PUBMED_11326105}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11326105 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11326105}}
 ==About this Structure==
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 [[Category: Pseudo-atomic model.]]
 [[Category: Virus]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:55:47 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 10:52:12 2008''