8b0a: Difference between revisions

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'''Unreleased structure'''


The entry 8b0a is ON HOLD  until Paper Publication
==Cryo-EM structure of ALC1 bound to an asymmetric, site-specifically PARylated nucleosome==
 
<StructureSection load='8b0a' size='340' side='right'caption='[[8b0a]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8b0a]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B0A FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b0a OCA], [https://pdbe.org/8b0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b0a RCSB], [https://www.ebi.ac.uk/pdbsum/8b0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b0a ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CHD1L_HUMAN CHD1L_HUMAN] ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:33357431, PubMed:34486521, PubMed:34874266, PubMed:34210977). Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34874266, PubMed:34486521). Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair (PubMed:19661379, PubMed:29220652, PubMed:29220653, PubMed:34874266, PubMed:34486521). Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner (PubMed:19661379, PubMed:29220652, PubMed:29220653). Chromatin remodeling activity promotes PARP2 removal from chromatin (PubMed:33275888).<ref>PMID:19661379</ref> <ref>PMID:29220652</ref> <ref>PMID:29220653</ref> <ref>PMID:33275888</ref> <ref>PMID:33357431</ref> <ref>PMID:34210977</ref> <ref>PMID:34486521</ref> <ref>PMID:34874266</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Xenopus laevis]]
[[Category: Bacic L]]
[[Category: Deindl S]]
[[Category: Gaullier G]]
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