7xs4: Difference between revisions
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/URT1_ARATH URT1_ARATH] UTP:RNA uridylyltransferase with a marked preference for uridine polymerization and a distributive activity for the first added nucleotides (PubMed:23748567, PubMed:25928405). Uridylates oligo(A)-tailed mRNAs to prevent 3' to 5' ribonucleotytic attacks (PubMed:23748567). Can prevent the 3' trimming of mRNAs still engaged on polysomes (PubMed:23748567). Acts synergistically with HESO1 in unmethylated miRNA uridylation, leading to their degradation (PubMed:25928341). URT1 and HESO1 prefer substrates with different 3' end nucleotides and act cooperatively to tail different forms of the same miRNAs (PubMed:25928405). URT1 and HESO1 act sequentially, with URT1 mono-uridylating the miRNAs followed by their further uridylation by HESO1 (PubMed:25928405). Has no effect on uridylation of heterochromatic siRNAs (PubMed:25928341). Able to act on AGO1-bound miRNAs and the uridylated species stay associated with AGO1 (PubMed:25928405).<ref>PMID:23748567</ref> <ref>PMID:25928341</ref> <ref>PMID:25928405</ref> | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 06:28, 26 October 2022
Crystal structure of URT1 in complex with AAAU RNA
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