1ih1: Difference between revisions

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[[Image:1ih1.gif|left|200px]]
{{Seed}}
[[Image:1ih1.png|left|200px]]


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{{STRUCTURE_1ih1|  PDB=1ih1  |  SCENE=  }}  
{{STRUCTURE_1ih1|  PDB=1ih1  |  SCENE=  }}  


'''Crystal Structure of the B-DNA Hexamer GGCGCC with Cobalt Hexamine Resolved to 2.0 Angstroms'''
===Crystal Structure of the B-DNA Hexamer GGCGCC with Cobalt Hexamine Resolved to 2.0 Angstroms===




==Overview==
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The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.
The line below this paragraph, {{ABSTRACT_PUBMED_11390969}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11390969 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11390969}}


==About this Structure==
==About this Structure==
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[[Category: Dna transition]]
[[Category: Dna transition]]
[[Category: Structural transition]]
[[Category: Structural transition]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:59:27 2008''
 
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