1ihf: Difference between revisions

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[[Image:1ihf.~~gif~~|left|200px]]

[[Image:1ihf.png|left|200px]]

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~~'''~~INTEGRATION HOST FACTOR/DNA COMPLEX~~'''~~

===INTEGRATION HOST FACTOR/DNA COMPLEX===

~~==Overview==~~

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~~Integration host factor~~ (~~IHF) is a small heterodimeric protein that specifically binds to DNA and functions~~ as ~~an architectural factor in many cellular processes in prokaryotes~~. ~~Here, we report the crystal structure of IHF complexed with 35 bp of DNA~~. ~~The DNA is wrapped around the protein and bent by >160 degrees~~, ~~thus reversing the direction of the helix axis within a very short distance. Much of the bending occurs at two large kinks~~ where ~~the base stacking~~ is ~~interrupted by intercalation of a proline residue. IHF contacts the DNA exclusively via the phosphodiester backbone and~~ the ~~minor groove and relies heavily on indirect readout to recognize its binding sequence~~. ~~One such readout involves a six~~-~~base A tract, providing evidence for the importance of a narrow minor groove.~~

The line below this paragraph, {{ABSTRACT_PUBMED_8980235}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 8980235 is the PubMed ID number.

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==About this Structure==

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[[Category: Dna bending protein]]

[[Category: Transcription factor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 20~~:00:04 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:11:44 2008''

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-[[Image:1ihf.gif|left|200px]]
+{{Seed}}
+[[Image:1ihf.png|left|200px]]
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 {{STRUCTURE_1ihf|  PDB=1ihf  |  SCENE=  }}
-'''INTEGRATION HOST FACTOR/DNA COMPLEX'''
+===INTEGRATION HOST FACTOR/DNA COMPLEX===
-==Overview==
+<!--
-Integration host factor (IHF) is a small heterodimeric protein that specifically binds to DNA and functions as an architectural factor in many cellular processes in prokaryotes. Here, we report the crystal structure of IHF complexed with 35 bp of DNA. The DNA is wrapped around the protein and bent by &gt;160 degrees, thus reversing the direction of the helix axis within a very short distance. Much of the bending occurs at two large kinks where the base stacking is interrupted by intercalation of a proline residue. IHF contacts the DNA exclusively via the phosphodiester backbone and the minor groove and relies heavily on indirect readout to recognize its binding sequence. One such readout involves a six-base A tract, providing evidence for the importance of a narrow minor groove.
+The line below this paragraph, {{ABSTRACT_PUBMED_8980235}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 8980235 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_8980235}}
 ==About this Structure==
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 [[Category: Dna bending protein]]
 [[Category: Transcription factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:00:04 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 12:11:44 2008''