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[[Image:1ihw.gif|left|200px]]
{{Seed}}
[[Image:1ihw.png|left|200px]]


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{{STRUCTURE_1ihw|  PDB=1ihw  |  SCENE=  }}  
{{STRUCTURE_1ihw|  PDB=1ihw  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 40 STRUCTURES'''
===SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 40 STRUCTURES===




==Overview==
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The solution structure of the DNA binding domain of HIV-1 integrase (residues 220-270) has been determined by multidimensional NMR spectroscopy. The protein is a dimer in solution, and each subunit is composed of a five-stranded beta-barrel with a topology very similar to that of the SH3 domain. The dimer is formed by a stacked beta-interface comprising strands 2, 3, and 4, with the two triple-stranded antiparallel beta-sheets, one from each subunit, oriented antiparallel to each other. One surface of the dimer, bounded by the loop between strands beta 1 and beta 2, forms a saddle-shaped groove with dimensions of approximately 24 x 23 x 12 A in cross section. Lys264, which has been shown from mutational data to be involved in DNA binding, protrudes from this surface, implicating the saddle-shaped groove as the potential DNA binding site.
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{{ABSTRACT_PUBMED_7632683}}


==About this Structure==
==About this Structure==
1IHW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHW OCA].  
1IHW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus Human immunodeficiency virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHW OCA].  


==Reference==
==Reference==
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[[Category: Dna-binding protein]]
[[Category: Dna-binding protein]]
[[Category: Polyprotein]]
[[Category: Polyprotein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:01:20 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:13:40 2008''

Revision as of 09:13, 1 July 2008

File:1ihw.png

Template:STRUCTURE 1ihw

SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF HIV-1 INTEGRASE, NMR, 40 STRUCTURES

Template:ABSTRACT PUBMED 7632683

About this Structure

1IHW is a Single protein structure of sequence from Human immunodeficiency virus. Full experimental information is available from OCA.

Reference

Solution structure of the DNA binding domain of HIV-1 integrase., Lodi PJ, Ernst JA, Kuszewski J, Hickman AB, Engelman A, Craigie R, Clore GM, Gronenborn AM, Biochemistry. 1995 Aug 8;34(31):9826-33. PMID:7632683

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