8e2a: Difference between revisions
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The entry | ==Human Dis3L2 in complex with hairpin D-U7== | ||
<StructureSection load='8e2a' size='340' side='right'caption='[[8e2a]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8e2a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E2A FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e2a OCA], [https://pdbe.org/8e2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e2a RCSB], [https://www.ebi.ac.uk/pdbsum/8e2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e2a ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/DI3L2_HUMAN DI3L2_HUMAN] Perlman syndrome;Nephroblastoma. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DI3L2_HUMAN DI3L2_HUMAN] 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.[HAMAP-Rule:MF_03045]<ref>PMID:23756462</ref> <ref>PMID:24141620</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Joshua-Tor L]] | |||
[[Category: Meze K]] | |||
[[Category: Thomas DR]] | |||
Revision as of 06:04, 2 March 2023
Human Dis3L2 in complex with hairpin D-U7
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