1ij9: Difference between revisions

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[[Image:1ij9.jpg|left|200px]]
{{Seed}}
[[Image:1ij9.png|left|200px]]


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{{STRUCTURE_1ij9|  PDB=1ij9  |  SCENE=  }}  
{{STRUCTURE_1ij9|  PDB=1ij9  |  SCENE=  }}  


'''Highly Hydrated Human VCAM-1 Fragment'''
===Highly Hydrated Human VCAM-1 Fragment===




==Overview==
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An X-ray crystal structure of two N-terminal integrin-binding IgSF domains of human VCAM-1 is reported. This new crystal form shows an unusual and highly hydrated packing arrangement in which over 80% of the crystal is occupied by solvent. The relative orientations of the two domains adopt a new intermediate conformation. The tilt angle between the two domains is 19.4 degrees, compared with other related structures that have tilt angles ranging from 7.3 to 39.9 degrees. An analysis of the torsion angles shows that residues Ile88, Tyr89, Ser90, Pro92 and Glu96 play a major role in defining the interdomain conformations.
The line below this paragraph, {{ABSTRACT_PUBMED_11679722}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11679722 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11679722}}


==About this Structure==
==About this Structure==
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[[Category: Walkinshaw, M D.]]
[[Category: Walkinshaw, M D.]]
[[Category: Integrin solvation]]
[[Category: Integrin solvation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:03:44 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 12:18:59 2008''
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