1ikf: Difference between revisions

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[[Image:1ikf.~~gif~~|left|200px]]

[[Image:1ikf.png|left|200px]]

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~~'''~~A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX~~'''~~

===A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX===

~~==Overview==~~

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The ~~conformation of~~ the ~~immunosuppressive drug cyclosporin A (CsA) in a complex with a Fab molecule has been established by crystallographic analysis~~ to ~~2.65 angstrom resolution. This conformation of CsA is similar to that recently observed in~~ the ~~complex with the rotamase cyclophilin, its binding protein in vivo, and totally different from its conformation in an isolated form~~ as ~~determined from x-ray and nuclear magnetic resonance analysis~~. ~~Because the surfaces of CsA interacting with cyclophilin or with the Fab are not identical~~, ~~these results suggest that the conformation of CsA observed in the bound form preexists in aqueous solution and~~ is ~~not produced by interaction with~~ the ~~proteins~~.

The line below this paragraph, {{ABSTRACT_PUBMED_1566062}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 1566062 is the PubMed ID number.

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==About this Structure==

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[[Category: Thierry, J C.]]

[[Category: Vix, O.]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 20~~:05:57 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:23:03 2008''

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-[[Image:1ikf.gif|left|200px]]
+{{Seed}}
+[[Image:1ikf.png|left|200px]]
 <!--
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 {{STRUCTURE_1ikf|  PDB=1ikf  |  SCENE=  }}
-'''A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX'''
+===A CONFORMATION OF CYCLOSPORIN A IN AQUEOUS ENVIRONMENT REVEALED BY THE X-RAY STRUCTURE OF A CYCLOSPORIN-FAB COMPLEX===
-==Overview==
+<!--
-The conformation of the immunosuppressive drug cyclosporin A (CsA) in a complex with a Fab molecule has been established by crystallographic analysis to 2.65 angstrom resolution. This conformation of CsA is similar to that recently observed in the complex with the rotamase cyclophilin, its binding protein in vivo, and totally different from its conformation in an isolated form as determined from x-ray and nuclear magnetic resonance analysis. Because the surfaces of CsA interacting with cyclophilin or with the Fab are not identical, these results suggest that the conformation of CsA observed in the bound form preexists in aqueous solution and is not produced by interaction with the proteins.
+The line below this paragraph, {{ABSTRACT_PUBMED_1566062}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 1566062 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_1566062}}
 ==About this Structure==
@@ Line 24: / Line 28: @@
 [[Category: Thierry, J C.]]
 [[Category: Vix, O.]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 20:05:57 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 13:23:03 2008''