1il6: Difference between revisions

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[[Image:1il6.jpg|left|200px]]
{{Seed}}
[[Image:1il6.png|left|200px]]


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{{STRUCTURE_1il6|  PDB=1il6  |  SCENE=  }}  
{{STRUCTURE_1il6|  PDB=1il6  |  SCENE=  }}  


'''HUMAN INTERLEUKIN-6, NMR, MINIMIZED AVERAGE STRUCTURE'''
===HUMAN INTERLEUKIN-6, NMR, MINIMIZED AVERAGE STRUCTURE===




==Overview==
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Interleukin-6 (IL-6) is a 185 amino acid cytokine which exerts multiple biological effects in vivo and whose dysregulation underlies several disease processes. The solution structure of recombinant human interleukin-6 has now been determined using heteronuclear three and four-dimensional NMR spectroscopy. The structure of the molecule was determined using 3044 distance and torsion restraints derived by NMR spectroscopy to generate an ensemble of 32 structures using a combined distance geometry/simulated annealing protocol. The protein contains five alpha-helices interspersed with variable-length loops; four of these helices constitute a classical four-helix bundle with the fifth helix located in the CD loop. There were no distance violations greater than 0.3 A in any of the final 32 structures and the ensemble has an average-to-the-mean backbone root-mean-square deviation of 0.50 A for the core four-helix bundle. Although the amino-terminal 19 amino acids are disordered in solution, the remainder of the molecule has a well defined structure that shares many features displayed by other long-chain four-helix bundle cytokines. The high-resolution NMR structure of hIL-6 is used to rationalize available mutagenesis data in terms of a heteromeric receptor complex.
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{{ABSTRACT_PUBMED_9159484}}


==About this Structure==
==About this Structure==
1IL6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IL6 OCA].  
1IL6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IL6 OCA].  


==Reference==
==Reference==
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[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Growth factor]]
[[Category: Growth factor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:07:14 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 13:26:50 2008''

Revision as of 10:26, 1 July 2008

Template:STRUCTURE 1il6

HUMAN INTERLEUKIN-6, NMR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 9159484

About this Structure

1IL6 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of recombinant human interleukin-6., Xu GY, Yu HA, Hong J, Stahl M, McDonagh T, Kay LE, Cumming DA, J Mol Biol. 1997 May 2;268(2):468-81. PMID:9159484

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